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Selective access to N -aryl or N -alkyl derivatives of isoindolo[2,1-b][2,4]benzo(or thieno)diazepines

Identifieur interne : 001B64 ( Main/Exploration ); précédent : 001B63; suivant : 001B65

Selective access to N -aryl or N -alkyl derivatives of isoindolo[2,1-b][2,4]benzo(or thieno)diazepines

Auteurs : Pascal Pigeon [France] ; Mohamed Othman [France] ; Pierre Netchitailo [France] ; Bernard Decroix [France]

Source :

RBID : ISTEX:DB3CDAAC3D824CFD9B78B00E9012E27AD565CD84

Abstract

N-alkyl isoindolo[2,1-b][2,4]benzodiazepines 15c were synthesized via an intramolecular N-acyliminium ion-amide reaction, N-aryl derivatives 8c were obtained from an intramolecular acylation of amino acids 6c in acetic anhydride. A generalization of these methodologies is given in the synthesis of the thiophenic analogues 15d and 8d.

Url:
DOI: 10.1016/S0040-4020(97)10359-3


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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